Careers

Current Openings

Associate Scientist/Scientist In-vivo Pharmacology

Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.

About the Position

We are seeking a cardiovascular physiologist/pharmacologist with experience characterizing animal models of disease and response to intervention. The successful candidate will be able to apply their knowledge of cardiovascular physiology to characterize small molecules to enable drug discovery programs. This is a lab-based position (~70%) primarily performing, hands-on, in vivo studies in rodents with remaining time spent analyzing data, meeting with key stakeholders to present results, and serving as a team representative. This role is based in Boulder, CO.

Primary Responsibilities

  • Requires thorough knowledge of varied aspects or a single specialized aspect of own discipline and developed knowledge of other related disciplines
  • Is proficient in scientific / technical writing (e.g., regulatory documents, protocols)
  • Applies scientific and / or technical skills and functional knowledge to conduct experiments / research / studies in assigned area
  • May adapt standard methods and techniques by applying breadth of knowledge and prior work experience
  • May contribute to initiatives related to continuous improvement or development of new approaches / technologies
  • Makes presentations in small, multidisciplinary meetings, logically presenting information to convey clear, key messages
  • May represent department or function on program / project team or sub-team
  • Perform in vivo studies to characterize and develop models of disease relevant to programs
  • Characterizes pharmacologic response to intervention
  • Lead studies to completion
  • Identify opportunities for protocol improvement and develop new experimental protocols
  • Document, critically review, modify experimental approach if necessary, and present experimental data in a timely manner
  • Collaborate with cross-functional teams in Research by providing timely and actionable study results

Requirements:

  • Bachelor’s or Master’s Degree
  • 4-6 years of academic and / or industry experience preferred
  • Hands-on experience handling and performing basic manipulations in rodents
  • Experience in performing rodent echocardiography and understanding of echocardiographic parameters
  • Experience in performing invasive hemodynamics assessment is preferred
  • Highly motivated- driven by achieving individual and team goals
  • Excellent laboratory skills, prioritizing accurate and reproducible work
  • Excellent organizational and time management skills
  • Must be self-motivated, detail-oriented, collaborative, and able to work effectively in a multidisciplinary team

Salary range: $75,000 – $105,000, title and salary commensurate with experience

Send resume and cover letter to recruiting@edgewisetx.com


Clinical Contracts Manager/Associate Director

Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.

About the Position

The Clinical Contracts Manager/Associate Director will manage key activities related to the outsourcing of clinical trials with a particular emphasis on vendor outsourcing (CROs and other clinical vendors) and contract and financial management of clinical service providers across multiple studies and global programs within Clinical Development. The candidate is ideally based in MA.

Primary Responsibilities

  • Collaborates with Clinical, Legal, other internal stakeholders, CRO(s), and vendors to negotiate confidentiality, ancillary, and vendor master service agreements (MSAs), scopes of work/work orders, and single service provider, consultant, and subcontractor agreements
  • Clinical contract expert serving as Clinical, Legal, and CRO liaison for clinical trial site agreements
  • Leads or assists in the development of request for proposals (RFPs), assessment, and selection of appropriate vendors, and collating, reviewing, tracking and analyzing vendor quotes and proposals
  • Coordinates and manages vendor bid defense meetings and associated follow-up as needed
  • Analyzes business practices and market conditions to evaluate bid responsiveness and contract/contractor performance
  • Negotiates directly with CROs and clinical vendors to obtain optimal pricing
  • Ensures that terms and conditions in vendor master service agreements, study-level contractual obligations, and trial site subject informed consent form templates align
  • Routes contracts for approval, signature, and filing and creates purchase orders according to companies processes and systems
  • Stays current with industry best-practices developing and implementing policies, procedures, and tools to standardize workflow and manage risk
  • Participates in the development and improvement of departmental processes and procedures
  • Maintains and ensures up-to-date documentation and records, performing periodic reconciliation of all active contracts with vendors
  • Other related tasks as needed

Requirements:

  • Senior level industry professional with 8+ years experience in contracts management, the majority of which has been in biotech/pharma/CRO and at least 2+ years in small biotech
  • Vast knowledge of clinical vendor and trial site agreements in US and globally, including EU and APAC
  • Proven strong analytical, negotiating, conflict resolution, and problem-solving skills
  • Effective cross-functional collaborator with excellent interpersonal, organizational, project management, time management, and written and oral communication skills
  • Ability to multi-task and shift priorities rapidly to meet tight deadlines
  • Enthusiastic, self-motivated, and keen to improve processes and overcome any inefficiencies
  • Proficient in Microsoft Office suite and applications with an understanding of GrantPlan and benchmarking tools
  • Bachelor’s degree required

Salary range: $120,000 – $180,000, title and salary commensurate with experience

Send resume and cover letter to recruiting@edgewisetx.com


Director, Analytical Chemist

Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.

About the Position

Edgewise Therapeutics is dedicated to advancing small molecule drug development programs focused in rare muscle disorders. This position is responsible for providing oversight for all the analytical development activities associated with drug substance and drug product to support preclinical studies, clinical development, and registration. The incumbent will be responsible for ensuring oversight of all the development activities and testing performed by contract laboratories, including starting materials, in-process, release, and stability testing for clinical development and pre-commercial.

Primary Responsibilities

  • Responsible for the development, validation, and transfers of all analytical methods from pre-clinical through clinical development.
  • Participate in selection of contract manufacturing organizations and contract laboratories and oversee development and validation of methods for reference standards, starting materials, intermediates, release, and stability testing of both drug substance and drug product.
  • Author and provide technical review of relevant Chemistry, Manufacturing and Controls (CMC) sections in regulatory dossiers.
  • Design and execute phase-appropriate analytical strategies at CSPs including analytical method development, qualification and validation for drug substance and drug product.
  • Develop and set specifications for raw materials, intermediates, drug substance, excipients and drug product.
  • Design and manage stability programs for non-GMP and cGMP drug substance and drug product batches and provide guidance for shelf-life and expiry dating.
  • Establish workflows and procedures for analytical and quality control activities.
  • Develop strategies for reference standards program, coordinate sourcing, ensure inventory, plan and execute testing and retesting activities, and manage shipments of reference standards across CSP network.
  • Manage and review deviation events and OOS/OOT investigations at CSPs in coordination with CMC counterparts, QA and regulatory team members, as appropriate.
  • Author, review and approve various analytical reports in a timely manner to support drug substance and drug product development and manufacture, and regulatory filings.
  • Support regulatory submissions by drafting and reviewing analytical sections of INDs, IMPDs, and NDAs, and ensure compliance with current regulatory requirements.
  • Represent analytical function in CMC teams and project meetings and work closely with cross-functional teams to meet project timelines and goals.
  • Keep abreast of latest progress in analytical development, cGMP requirements, and regulatory guidances.

Requirements:

  • PhD in analytical chemistry or related discipline with more than 10 years of industry experience or BS/MS degree with more than 15 years industry experience
  • Experience with analytical development of small molecules and solid oral dosage forms from preclinical to late-stage clinical development.
  • Experience managing analytical CMC development of drug substance and drug products from pre-clinical through registration and approval.
  • Expert level knowledge of analytical method development and method qualification/validation
  • Experience interpreting ICH and FDA guidance for analytical method qualification/validation, stability testing.
  • Extensive knowledge of GLP and cGMP requirements, appropriate regulatory guidance and current industry practices for analytical development.
  • Experience authoring analytical modules for regulatory submissions in all phases of development.
  • Experience with identification and qualification of impurities and degradation products.
  • Experience with setting specifications for drug substance and drug product and qualifying reference standards.
  • Demonstrated scientific excellence, technical leadership, and creativity.
  • Proven project management skills and productive collaboration with cross-functional teams.
  • Ability to deliver under tight timelines and adapt to changing project needs.
  • Ability to work on multiple projects at the same time.
  • Ability to communicate, organize, and write well.

Salary range: $155,000 – $225,000, title and salary commensurate with experience

Send resume and cover letter to recruiting@edgewisetx.com


Director/Senior Director, Cardiovascular Pharmacology

Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.

About the Position

Cardiovascular leadership position for a proven scientist in the field capable of both performing and leading and in vivo scientific efforts. Broad range of responsibilities, including designing, managing, and leading scientist to perform high-quality experiments, establishing, and managing collaborations, analyzing and reporting data, and contributing intellectually to scientific research as it relates to advancing company goals. The right candidate may lead the in vivo function and be responsible for leading a project team. This position will be based in Boulder, Colorado.

Primary Responsibilities

  • Independently design, manage, and execute experiments in context of scientific goals across the company’s ongoing pharmacology projects
  • Manage internal and external teams that conduct detailed and complex wet laboratory experiments with appropriate technique and adequate controls satisfactory to substantiate/replicate results
  • Contribute to the coordination and direction of research among the company’s scientific disciplines as they relate to assigned projects
  • Manage a group of independent researchers
  • Research and identify new opportunities and project ideas that complement the company’s mission, vision, values, and goals
  • Establish appropriate objectives in the formulation of successful project strategy
  • Influence the direction of company programs by designing experiments and collaborations, interpreting, analyzing, and correlating data from multiple sources, overcoming obstacles, and delivering results within project timelines
  • Demonstrate a high level of resourcefulness through exceptional scientific knowledge and superior technical skills
  • Actively increase team or group performance by critically reviewing work processes while offering insightful input and suggestions
  • Produce and review individual and team scientific reports/presentations for internal and/or external purposes
  • Work closely with consultants and collaborators to understand results and how they impact project goals
  • Demonstrate a strong level of participation and/or lead at project team meetings
  • Contribute advanced-level scientific perspective to patent efforts
  • Update job knowledge by attending scientific meetings; participating in educational opportunities; reading professional publications; maintaining professional networks; and participating in professional organizations
  • Read, understand, and comply with all workplace health and safety policies; safe work practices; and company policies and procedures

Requirements:

  • Ph.D. in cardiovascular physiology or closely related field; post-doctoral and industry experience required
  • 10+ years of academic/research laboratory experience
  • Exceptional understanding of scientific literature in respective area of science/research
  • Demonstrated cardiovascular expertise (publication track record)
  • Technical expertise in both in vitro and in vivo cardiovascular techniques across a range of species, with strong molecular and multi-omics expertise.
  • Demonstrated ability to work independently and to lead independent scientists.
  • Familiarity with safe and efficient laboratory practices/li>
  • General scientific computer and software application proficiency

Salary range: $210,000 – $275,000, title and salary commensurate with experience

Send resume and cover letter to recruiting@edgewisetx.com


Executive Administrative Assistant

Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.

About the Position

This position supports the executive management team in a confidential and highly responsible capacity. The incumbent projects a professional company image through in-person, virtual and phone interactions.

Primary Responsibilities

Administrative:

  • Manage calendars of executive team members and conference rooms
  • Keep executive team members well informed of upcoming commitments and responsibilities
  • Schedule internal and external meetings, prepare meeting materials, logistics and meeting minutes
  • Screen telephone calls and business visitors, routing inquiries to appropriate personnel
  • Develop complex and detailed travel itineraries and agendas; book all travel accommodations
  • Arrange meetings, meals, events, and other corporate functions
  • Complete expense reports for executive team members
  • Arrange transportation for visitors when necessary
  • Prepare and edit correspondence and documents
  • Assemble complex data from various sources to produce detailed tables, charts, and reports
  • Follow up on assignments to ensure decisions are implemented and appropriate resources are allocated
  • Communicate directly with consultants, collaborators, and stakeholders as needed
  • Prioritize, problem solve problems, and research to resolve issues
  • Act as Project Manager for special projects including organizing companywide events
  • Partner with other administrative personnel on appropriate activities (i.e. company-wide events)

Board Support:

  • Serve as administrative liaison to company’s board of directors and scientific advisory board
  • Arrange board meetings and assist board members with travel arrangements
  • Manage board report process in an expeditious and proactive manner
  • Maintain discretion and confidentiality in relationships with all board members
  • Perform other duties as assigned

Requirements:

  • High level of interpersonal skills to handle sensitive and confidential situations
  • Demonstrated poise, tact and diplomacy
  • Exceptional verbal and written communication skills and the ability to interact with individuals at all levels of the organization
  • Ability to work effectively in a fast-paced environment juggling multiple competing tasks and demands
  • Excellent calendar management skills
  • Strong detail orientation with the ability to prioritize and work independently with limited supervision
  • Ability to be flexible team player and manage frequent changes
  • Strong time management skills and ability to work under tight timelines
  • Excellent customer service and interpersonal skills
  • High school diploma required, bachelors degree preferred
  • Minimum of 8 years administrative work experience required
  • C-level executive support required, prior experience as a Board liaison preferred
  • Advance computer proficiency (MS Word, Excel, PowerPoint)
  • Strong analytical skills
  • Detail oriented with demonstrable organizational skills

Salary range: $70,000 – $130,000, title and salary commensurate with experience

Send resume and cover letter to recruiting@edgewisetx.com


Legal Affairs Counsel

Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.

About the Position

The Legal Affairs Counsel will provide general legal support for Edgewise Therapeutics’ R&D operations, primarily by handling a wide range of agreements for both on-going and new discovery and development programs.

Primary Responsibilities

  • Provide legal support and substantive advice primarily to Edgewise’s R&D functions, including Discovery, Clinical Operations, CMC and Regulatory Affairs, and secondarily to general and administrative functions of the company, including Project Management, IT, and Finance.
  • Draft, review, negotiate, and interpret a high volume and wide range of agreements, including confidentiality, material transfer, services, consulting, sponsored research, clinical trial and investigator-initiated trial agreements.
  • Identify, develop and implement business process improvements to enhance delivery of legal support for transactions and related business decision-making.
  • Identify training needs within client groups and assist in the development and presentation of training on relevant laws, regulations and legal/business issues.
  • Maintain frequent contact with all client functions within the company, managing requests and prioritization of projects.

Requirements:

  • JD degree from an accredited law school.
  • Excellent academic and law firm credentials.
  • Must have 3-7 years of relevant prior experience handling complex commercial contracts at a law firm with a nationally recognized Life Sciences/Pharma/Biotech practice or in-house at a pharma/biotech organization.
  • Science background a plus.
  • Must be licensed to practice law in at least one (1) state and in good standing.
  • Significant experience drafting, reviewing, and negotiating a wide variety of complex pharma-related agreements.
  • Excellent skills in verbal and written communication, with ability to distill complex legal issues to essential elements for clients throughout the organization with different abilities and responsibilities.
  • Strong organizational skills in order to prioritize and manage multiple time-sensitive projects simultaneously; willingness to assume heavy workload to meet timing and project needs.
  • A demonstrated ability to grasp scientific and technical concepts quickly.
  • Ability to collaborate, as well as work independently, balancing competing priorities.
  • Strong client-support skills.
  • Attention to detail.
  • High business acumen with the ability to appropriately balance legal and business risks in an ethical and compliant manner.

Salary range: $120,000 – $200,000, title and salary commensurate with experience

Send resume and cover letter to recruiting@edgewisetx.com


Manager, Clinical Drug Supply Chain

Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.

About the Position

Edgewise Therapeutics is dedicated to advancing small molecule drug development programs focused in rare muscle disorders. The Manager, Clinical Drug Supply Chain is responsible for forecasting Investigational Product (IP) supply requirements for multiple clinical trials and for managing the IP distribution process to one or more clinical trials. Activities are performed on time, within budget and with good quality, in compliance with Regulatory Authorities’ regulations / guidelines. Contributes to ongoing process improvement initiatives. Collaborates and interacts with clinical trial managers, as well as staff from quality, clinical compliance, regulatory, and (CMC, external manufacturing, stability).

Primary Responsibilities

  • Serves as lead drug supply manager in supply planning, including demand forecasting according to clinical development requirements.
  • Leads supply planning and timelines to ensure alignment with study plans and timelines and overall clinical development plan.
  • Provides input to the development of IP-related study documents including protocols, study, and pharmacy manuals.
  • Is responsible for working within established timelines of investigational product manufacturing, labeling, release, distribution, and return/destruction, and/or helping to establish these timelines.
  • Is responsible for investigational product (IP) inventory strategy; advises supply management team of potential shortages and defines resupply activities based on usage trends and projections.
  • Has a solid understanding and experience with Interactive Response Technologies (IRT) such as IVRS and IWRS.
  • Works with cross-functional teams to develop specifications and support user testing of IRT systems provided by 3rd party vendors.
  • Leads effort for clinical supply management functionality.
  • Monitors clinical supply activities through IRT from study start-up through study closure.
  • Develops strategy and oversees drug return and destruction activities.
  • Develops resupply strategies based on stability and shelf-life of clinical supplies.
  • Monitors IP expiry data and informs Clinical Trial teams of pending IP expiry.
  • Coordinates with other functional areas, to define ancillary and/or comparator supply strategy.
  • Provides feedback to drug kit randomization specifications and reviews and approves master kit lists.
  • Designs, reviews, and approves IP-related study tools (for clinical study teams and investigative site use), as needed.
  • Provides input into budgets, SoWs, contracts, and timelines for IP-related services.
  • Creates RFPs, reviews quotes, and awards third-party vendors for distribution services.
  • Responsible for distribution vendor budget management (invoice review/approval, change orders, reconciliation); reviews and approves/scrutinizes specified costs on vendor invoices against contract, as delegated.
  • Leads management of IP service vendors (performance, quality, timelines, results, costs).
  • Participates in preparation of RFP, assumptions, and SOW for CROs and IP services vendors (labeling, packaging, distribution; IVRS/IWRS).
  • Provides input, reviews, and approves vendor study specifications for IP-related activities.
  • Serves as point of escalation for vendor-related IP issues as they arise.

Requirements:

  • Bachelor's Degree or at least 5 years of relevant experience in the biotechnology/pharmaceutical industry, with 3 years minimum in clinical supply management.
  • May require up to 10% travel.

Salary range: $70,000 – $140,000, title and salary commensurate with experience

Send resume and cover letter to recruiting@edgewisetx.com


Manager/Associate Director, Preclinical Research Outsourcing

Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.

About the Position

The Manager/Associate Director, Outsourcing will manage key activities related to the outsourcing of preclinical studies, including IND-enabling studies, with a particular emphasis on vendor outsourcing, sponsored research (CROs, GLP and non-GLP labs, other preclinical vendors and universities) and contract and financial management of service providers across multiple programs within Drug Discovery.

Primary Responsibilities

  • Lead RFP process (including vendor evaluation and vendor selection) for preclinical service provider needs (CROs, GLP and non-GLP labs and other preclinical vendors) for new clinical studies of various phases and sizes and complexity and risk. Includes assessing vendor capabilities, as well as leading the study teams through the process of analyzing complex budget scenarios, bids, and outsourcing models to determine best value and best fit.
  • Manage and lead financial negotiations with external service providers including analysis of complex, detailed scopes of work, exhibits, payment terms, significant budgets, MSAs and Change Orders for assigned studies/programs. Liaise with legal on contract negotiations.
  • Serve as primary point of contact to the CROs, vendors and universities in resolving contract scope and financial issues for assigned programs/vendors and managing and escalating issues accordingly.
  • Manage review of contract business terms and partner with Legal, Finance and other internal stakeholders as needed.
  • Partner with preclinical program team members to create specifications for work to be outsourced; determine and assess candidate vendors based on capabilities, capacity, strategic fit, expertise, quality, performance and price, assist in providing test materials to vendors/universities.
  • Manage vendor relationships and oversee vendor performance (including financial relationship management) to ensure compliance against contracted services, including receipt of results, for outsourced work and escalate issues as appropriate.
  • Manage vendor financials for assigned studies/programs/vendor relationships including negotiation of payment terms and schedules, invoice review, tracking of Purchase Order utilization to budget/plan, escalation and resolution of payment issues.
  • Evaluate and optimize/enhance key business processes and establish best practices with internal and external stakeholders and business relationships and represent Outsourcing in process initiatives.
  • Ensure timely study execution in support of corporate and department goals within financial plan.
  • Provide oversight of vendors to ensure management of the project’s scope, contract, and finances; ensure that any contractual changes in scope are communicated, negotiated, documented, and transparently proportional to actual activity or incurred cost.
  • Drive Outsourcing process improvement efforts.

Requirements:

  • Degree in Life Sciences (or equivalent)
  • 3-5 years of experience in preclinical research environment or comparable applicable experience; understanding of scientific terminology, business practice, process, timeline and key budget drivers
  • Previous experience working with CROs and other service providers
  • Procurement expertise (preclinical research or services)
  • Contract management and negotiation experience required (budget and business terms and conditions)
  • Proven ability to build and maintain effective internal and external relationships
  • Must have strong analytical, negotiating and business communication skills
  • Must be self-motivating and be able to prioritize and manage a large volume of work, handle a moderate amount of pressure, and show attention to detail
  • Proficient with Microsoft Office
  • Experience and confidence working with multiple functional areas and facilitating communication across multiple levels of internal/external teams.
  • Familiarity with GLP a plus.
  • Excellent interpersonal skills and professional attitude are essential as this individual interacts with many people of varying levels of responsibility for preclinical studies and business performance.

Salary range: $85,000 – $160,000, title and salary commensurate with experience

Send resume and cover letter to recruiting@edgewisetx.com


Principal Scientist, Pharmacology

Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.

About the Position

Cardiovascular scientific position with for an upcoming leader in the field capable of both performing and leading multi-omics, molecular, in vitro, and in vivo scientific efforts. Broad range of responsibilities, including designing, managing, and executing high-quality experiments, establishing, and managing collaborations, analyzing and reporting data, and contributing intellectually to scientific research as it relates to advancing company goals. The Senior Scientist may be responsible for leading a project group.

Primary Responsibilities:

  • Independently design, manage, and execute experiments in context of scientific goals across the company’s ongoing projects
  • Conduct and/or manage a team that conducts detailed and complex wet laboratory experiments with appropriate technique and adequate controls satisfactory to substantiate/replicate results
  • Contribute to the coordination and direction of research among the company’s scientific disciplines as they relate to assigned projects
  • Manage a group of independent researchers
  • Research and identify new opportunities and project ideas outside of assigned both the work and the company that complement the company’s mission, vision, values, and goals
  • Establish appropriate objectives in the formulation of successful project strategy
  • Influence the direction of company programs by designing experiments and collaborations, interpreting, analyzing, and correlating data from multiple sources, overcoming obstacles, and delivering results within project timelines
  • Demonstrate a high level of resourcefulness through exceptional scientific knowledge and superior technical skills
  • Actively increase team or group performance by critically reviewing work processes while offering insightful input and suggestions
  • Produce and review individual and team scientific reports/presentations for internal and/or external purposes
  • Work closely with consultants and collaborators to understand results and how they impact project goals
  • Demonstrate a strong level of participation at project team meetings
  • Maintain scientific records in clear required form
  • Contribute advanced-level scientific perspective to patent efforts
  • Update job knowledge by attending scientific meetings; participating in educational opportunities; reading professional publications; maintaining professional networks; and participating in professional organizations
  • Read, understand, and comply with all workplace health and safety policies; safe work practices; and company policies and procedures
  • Perform other duties as assigned by supervisor

Requirements:

EDUCATION, EXPERIENCE, SKILLS:

  • Ph.D. in cardiovascular physiology or closely related field; post-doctoral and industry experience required
  • 7+ years of academic/research laboratory experience
  • Exceptional understanding of scientific literature in respective area of science/research
  • Demonstrated cardiovascular expertise (publication track record)
  • Technical expertise in both in vitro and in vivo cardiovascular techniques across a range of species, with strong molecular and multi-omics expertise
  • Demonstrated ability to work independently and to lead independent scientists
  • Familiarity with safe and efficient laboratory practices
  • General scientific computer and software application proficiency

Salary range: $120,000 – $190,000. Salary will depend on experience level.

Travel: The preference is to have this position based in Colorado. If the incumbent is not local, a hybrid situation with 50% time on-site would be acceptable.

Send resume and cover letter to recruiting@edgewisetx.com


Scientist, Medicinal Chemistry

Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.

About the Position

Edgewise is seeking a synthetic medicinal chemist, eager to contribute to the discovery of novel small-molecule drugs. As a Senior Scientist in Medicinal Chemistry, you will work as part of an interdisciplinary team of scientists to discover novel small molecule therapeutics. You will be responsible for the design and synthesis of novel compounds for ongoing and emerging projects and identification and application of SAR to compound design. You will work in a team-driven environment to achieve optimization of clinical candidates. Responsibilities may also include management of CRO-driven collaborations, work with the CMC team on translation to large scale chemistries of successful candidates, and contribution to patent and publication preparation.

Primary Responsibilities:

  • Utilize synthetic organic chemistry to investigate, identify, develop, and optimize methods
  • Initiate and execute the design, synthesis, purification and characterization of organic small molecules via multi-step synthesis
  • Propose and explore alternative synthetic routes and synthetic strategies, troubleshoot reactions and multistep reaction sequences
  • Generation of new scientific synthetic and medicinal chemistry proposals for lead optimization efforts
  • Lead the development, execution and/or contribute ideas for novel small molecules based on SAR, X-Ray crystallography and scientific literature
  • Oversee and effectively manage CRO chemists
  • Interact with vendors to meet program requiements
  • Maintain close collaborations and/or manage and mentor fellow chemists and researchers across disciplines in a team environment
  • Maintain a command of relevant scientific literature and incorporate into individual project(s) as well as the overall program
  • Engage in medicinal chemistry discussions and drive decision-making on compounds
  • Prepare and present research results in chemistry and project team meetings and deliver scientific presentations and data to colleagues within and outside the company
  • Maintain clear, detailed, and up-to-date records of research using electronic laboratory notebooks
  • Manage internal scientific databases

Requirements:

EDUCATION, EXPERIENCE, SKILLS:

  • Degree in Organic Chemistry with a focus on modern synthetic organic chemistry with typically, 8+ (BS) or 5+(MS) years of experience; Pharmaceutical industry experience desirable
  • Understanding of ADME, physicochemical properties, and principles of medicinal chemistry
  • Skilled in the art and practice of modern synthetic and mechanistic organic chemistry with demonstrated experience in designing and executing multistep synthesis of complex organic molecules
  • Competence with the use of modern spectroscopic methods applied to structure determination including 1H NMR, 13C NMR, IR and mass spectroscopy
  • Demonstrate the ability to resolve key scientific hurdles by effectively utilizing available information and technical expertise
  • Exceptional communication skills; ability to develop, implement and clearly communicate chemistry strategies and progress to team
  • Build strong relationships with peers and cross functionally with partners outside of teams to enable high performance
  • Self-motivated with the ability to work independently and effectively in a team-oriented, multidisciplinary environment
  • Familiarity with safe and efficient laboratory practices
  • General scientific computer and software application proficiency

Salary range: $85,000 – $150,000. Salary will depend on experience level.

Send resume and cover letter to recruiting@edgewisetx.com


Senior Scientist, Medicinal Chemistry

Edgewise Therapeutics has an exciting role in a rapidly growing, innovative clinical-stage biopharmaceutical company focused on rare muscle disorders.

About the Position

Edgewise is seeking a synthetic medicinal chemist, eager to contribute to the discovery of novel small molecule drugs. As a Senior Scientist in Medicinal Chemistry, you will work as part of an interdisciplinary team of scientists to discover novel small molecule therapeutics. You will be responsible for the design and synthesis of novel compounds for ongoing and emerging projects and identification and application of SAR to compound design. You will work in a team-driven environment to achieve optimization of clinical candidates. Responsibilities may also include management of CRO-driven collaborations, work with the CMC team on translation to large scale chemistries of successful candidates, and contribution to patent and publication preparation.

Primary Responsibilities:

  • Utilize synthetic organic chemistry to investigate, identify, develop, and optimize methods
  • Initiate and execute the design, synthesis, purification and characterization of organic small molecules via multi-step synthesis
  • Propose and explore alternative synthetic routes and synthetic strategies, troubleshoot reactions and multistep reaction sequences
  • Generation of new scientific synthetic and medicinal chemistry proposals for lead optimization efforts
  • Lead the development, execution and/or contribute ideas for novel small molecules based on SAR, X-Ray crystallography and scientific literature
  • Oversee and effectively manage CRO chemists
  • Interact with vendors to meet program requiements
  • Maintain close collaborations and/or manage and mentor fellow chemists and researchers across disciplines in a team environment
  • Maintain a command of relevant scientific literature and incorporate into individual project(s) as well as the overall program
  • Engage in medicinal chemistry discussions and drive decision-making on compounds
  • Prepare and present research results in chemistry and project team meetings and deliver scientific presentations and data to colleagues within and outside the company
  • Maintain clear, detailed, and up-to-date records of research using electronic laboratory notebooks
  • Manage internal scientific databases

Requirements:

EDUCATION, EXPERIENCE, SKILLS:

  • Degree in Organic Chemistry with a focus on modern synthetic organic chemistry with typically, 10+ (BS), 8+(MS) or 4+(PhD) years of experience; Postdoctoral or pharmaceutical industry experience desirable
  • Understanding of ADME, physicochemical properties, and principles of medicinal chemistry
  • Skilled in the art and practice of modern synthetic and mechanistic organic chemistry with demonstrated experience in designing and executing multistep synthesis of complex organic molecules
  • Competence with the use of modern spectroscopic methods applied to structure determination including 1H NMR, 13C NMR, IR and mass spectroscopy
  • Demonstrate the ability to resolve key scientific hurdles by effectively utilizing available information and technical expertise
  • Exceptional communication skills; ability to develop, implement and clearly communicate chemistry strategies and progress to team
  • Build strong relationships with peers and cross functionally with partners outside of teams to enable high performance
  • Self-motivated with the ability to work independently and effectively in a team-oriented, multidisciplinary environment
  • Familiarity with safe and efficient laboratory practices
  • General scientific computer and software application proficiency

Salary range: $100,000 – $175,000. Salary will depend on experience level.

Send resume and cover letter to recruiting@edgewisetx.com