Posters and Publications
Scientific Presentations and Publications
Edgewise presents original research on its science and therapeutic development at scientific and medical conferences, as well as in published peer-reviewed scientific journals.
Please contact us if you would like to learn more about the research presented here.
Skeletal
March 2024
Functional and Muscle Damage Biomarker Changes Following Treatment with EDG-5506, a Fast Myosin Modulator, in Adults with Becker Muscular Dystrophy
2024 MDA Annual Clinical and Scientific Conference
Skeletal
March 2024
Protecting and preserving dystrophic muscle: The balance between exercise and contraction-induced muscle injury
2024 MDA Annual Clinical and Scientific Conference Industry Forum
Skeletal
March 2024
Characterization of Short- and Long-Term Proteomic Response to the Fast Skeletal Myosin Inhibitor, EDG-5506, in Becker Muscular Dystrophy (BMD)
2024 MDA Annual Clinical and Scientific Conference
Skeletal
March 2024
Functional and Muscle Damage Biomarker Changes Following Treatment with EDG-5506, a Fast Myosin Modulator, in Adults with Becker Muscular Dystrophy (Becker)
2024 MDA Annual Clinical and Scientific Conference
Skeletal
March 2024
North Star (NSAA and NSAD) Functional Assessments in Individuals with Becker Muscular Dystrophy
2024 MDA Annual Clinical and Scientific Conference
Cardiovascular
November 2023
Targeting the Mechanism of Hypertrophic Cardiomyopathy
Global CVCT Forum
Cardiovascular
November 2023
EDG-7500, A Carciac Sarcomere Regulator that Preserves Intrinsic Myosin-Motor Function, Improves Cardiac Function and Reserve in a Minipig Model of HCM
American Heart Association Scientific Sessions 2023
Cardiovascular
November 2023
Cardiac Effects of EDG-7500, a Novel Cardiac Sarcomere Regulator: In Vitro and In Vivo Evidence for Slowing Isovolumic Contraction and Improved Ventricular Compliance
American Heart Association Scientific Sessions 2023
Skeletal
October 2023
It’s Time to Get Real About Becker Muscular Dystrophy: Using Qualitative Research to Understand the Lived Experience and Give Voice to an Underserved Community
NORD Rare Diseases & Orphan Products Breakthrough Summit
Cardiovascular
October 2023
Targeting the Mechanism of Hypertrophic Cardiomyopathy
2023 HCM Society Annual Scientific Sessions
Cardiovascular
October 2023
A Phase 1, Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of EDG-7500 in Healthy Adults
Heart Failure Society of America Annual Scientific Meeting
Skeletal
October 2023
Effects of EDG-5506, a Fast Myosin Modulator, on Function and Biomarkers of Muscle Damage in Adults with Becker Muscular Dystrophy
2023 International Annual Congress of the World Muscle Society
Skeletal
October 2023
Characterization of Short- and Long-Term Proteomic Response to the Fast Skeletal Myosin Inhibitor, EDG-5506, in Becker Muscular Dystrophy
2023 International Annual Congress of the World Muscle Society
Skeletal
October 2023
Development of a conceptual model of the patient experience of Becker Muscular Dystrophy
2023 International Annual Congress of the World Muscle Society
Skeletal
October 2023
Becker Muscular Dystrophy Natural History and ARCH, an Open Label Study in Becker: Putting the Data into Context
2023 International Annual Congress of the World Muscle Society
Skeletal
June 2023
EDG-5506: A Novel Approach to Protect Muscle in Duchenne Muscular Dystrophy
2023 PPMD Annual Conference
Skeletal
June 2023
EDG-5506: A Novel Approach Designed to Protect Muscle in Becker Muscular Dystrophy
2023 PPMD Annual Conference
Skeletal
March 2023
Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy
The Journal of Clinical Investigation
Skeletal
March 2023
Targeting Fast Muscle Myosin: A Novel Approach to Protecting Muscle in the Dystrophinopathies
2023 MDA Annual Clinical and Scientific Conference Industry Forum
Skeletal
March 2023
Fast Skeletal Myosin Modulator EDG-5506 Confers Additional Protection to mdx Mice Receiving Glucocorticoid Treatment
2023 MDA Annual Clinical and Scientific Conference
Skeletal
March 2023
Plasma Metabolic Profiling Suggests Enrichment of Glycolytic Pathways Over Fatty Acid Oxidation in Becker Muscular Dystrophy
2023 MDA Annual Clinical and Scientific Conference
Cardiovascular
March 2023
EDG-7500 (EDG-002), A First-in-Class Targeted Sarcomere Regulator that Preserves Intrinsic Myosin-Motor Function, Normalizes Systolic Function and Eliminates LVOT Obstruction in Cats with Hypertrophic Cardiomyopathy
American College of Cardiology (ACC) Annual Scientific Session & Expo 2023
Skeletal
October 2022
Targeting Fast Muscle Myosin: A Novel Approach to Protecting Muscle in the Dystrophinopathies
2022 Annual Congress of the World Muscle Society
Skeletal
October 2022
Clinical Development of EDG-5506 in Duchenne and Becker Muscular Dystrophy
2022 Annual Congress of the World Muscle Society
Skeletal
October 2022
Patient Reported Aspects of Becker Muscular Dystrophy from The Duchenne Registry a Comprehensive Registry for Duchenne and Becker Muscular Dystrophy (BMD)
2022 Annual Congress of the World Muscle Society
Skeletal
June 2022
Insights into the Becker Muscular Dystrophy Experience from the Duchenne Registry, a Comprehensive Registry for Duchenne and Becker Muscular Dystrophy
2022 PPMD Annual Conference
Skeletal
June 2022
Understanding the Becker Muscular Dystrophy (BMD) Experience from the Patient Perspective: It’s More Than Mild Duchenne
2022 PPMD Annual Conference
Skeletal
June 2022
Use of an Exercise Challenge System to Define a Universal Proteomic Signature of Muscle Injury in a Diverse Set of Adult Individuals with Inherited Myopathy
New Directions Biology and Disease of Skeletal Muscle Conference 2022
Skeletal
May 2022
Manipulating the Dark Side of Muscle Adaptation for Therapeutic Gain
13th Annual GoldLab Symposium
Skeletal
March 2022
EDG 5506 Targets Fast Skeletal Myosin to Protect Dystrophic Muscle and Reduce Muscle Damage Biomarkers in a Phase 1 Trial in Becker Muscular Dystrophy
2022 MDA Clinical and Scientific Conference
Skeletal
March 2022
EDG-5506 Targets Fast Skeletal Myosin to Protect Dystrophic Muscle and Reduce Muscle Damage Biomarkers in a Phase 1 Trial in Becker Muscular Dystrophy
2022 MDA Clinical and Scientific Conference
Skeletal
May 2021
Elevation of fast but not slow troponin I in the circulation of patients with Becker and Duchenne muscular dystrophy
Muscle & Nerve, March 8, 2021