Posters and Publications

Scientific Presentations and Publications

Edgewise presents original research on its science and therapeutic development at scientific and medical conferences, as well as in published peer-reviewed scientific journals.

Please contact us if you would like to learn more about the research presented here.

Cardiovascular

April 2024

Chronic Treatment with the Novel Sarcomere Modulator EDG-7500 Improves Left Ventricular Distensibility and Cardiac Output Recruitment Under Stress in a Mini-pig Genetic Model of Non-Obstructed Hypertrophic Cardiomyopathy

ACC Annual Scientific Session

Skeletal

March 2024

Functional and Muscle Damage Biomarker Changes Following Treatment with EDG-5506, a Fast Myosin Modulator, in Adults with Becker Muscular Dystrophy

2024 MDA Annual Clinical and Scientific Conference

Skeletal

March 2024

Protecting and preserving dystrophic muscle: The balance between exercise and contraction-induced muscle injury

2024 MDA Annual Clinical and Scientific Conference Industry Forum

Skeletal

March 2024

Characterization of Short- and Long-Term Proteomic Response to the Fast Skeletal Myosin Inhibitor, EDG-5506, in Becker Muscular Dystrophy (BMD)

2024 MDA Annual Clinical and Scientific Conference

Skeletal

March 2024

Functional and Muscle Damage Biomarker Changes Following Treatment with EDG-5506, a Fast Myosin Modulator, in Adults with Becker Muscular Dystrophy (Becker)

2024 MDA Annual Clinical and Scientific Conference

Skeletal

March 2024

North Star (NSAA and NSAD) Functional Assessments in Individuals with Becker Muscular Dystrophy

2024 MDA Annual Clinical and Scientific Conference

Cardiovascular

November 2023

Targeting the Mechanism of Hypertrophic Cardiomyopathy

Global CVCT Forum

Cardiovascular

November 2023

EDG-7500, A Carciac Sarcomere Regulator that Preserves Intrinsic Myosin-Motor Function, Improves Cardiac Function and Reserve in a Minipig Model of HCM

American Heart Association Scientific Sessions 2023

Cardiovascular

November 2023

Cardiac Effects of EDG-7500, a Novel Cardiac Sarcomere Regulator: In Vitro and In Vivo Evidence for Slowing Isovolumic Contraction and Improved Ventricular Compliance

American Heart Association Scientific Sessions 2023

Skeletal

October 2023

It’s Time to Get Real About Becker Muscular Dystrophy: Using Qualitative Research to Understand the Lived Experience and Give Voice to an Underserved Community

NORD Rare Diseases & Orphan Products Breakthrough Summit

Cardiovascular

October 2023

Targeting the Mechanism of Hypertrophic Cardiomyopathy

2023 HCM Society Annual Scientific Sessions

Cardiovascular

October 2023

A Phase 1, Randomized, Double-blind, Placebo-controlled, Single and Multiple Ascending Dose Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of EDG-7500 in Healthy Adults

Heart Failure Society of America Annual Scientific Meeting

Skeletal

October 2023

Effects of EDG-5506, a Fast Myosin Modulator, on Function and Biomarkers of Muscle Damage in Adults with Becker Muscular Dystrophy

2023 International Annual Congress of the World Muscle Society

Skeletal

October 2023

Characterization of Short- and Long-Term Proteomic Response to the Fast Skeletal Myosin Inhibitor, EDG-5506, in Becker Muscular Dystrophy

2023 International Annual Congress of the World Muscle Society

Skeletal

October 2023

Development of a conceptual model of the patient experience of Becker Muscular Dystrophy

2023 International Annual Congress of the World Muscle Society

Skeletal

October 2023

Becker Muscular Dystrophy Natural History and ARCH, an Open Label Study in Becker: Putting the Data into Context

2023 International Annual Congress of the World Muscle Society

Skeletal

June 2023

EDG-5506: A Novel Approach to Protect Muscle in Duchenne Muscular Dystrophy

2023 PPMD Annual Conference

Skeletal

June 2023

EDG-5506: A Novel Approach Designed to Protect Muscle in Becker Muscular Dystrophy

2023 PPMD Annual Conference

Skeletal

March 2023

Modulating fast skeletal muscle contraction protects skeletal muscle in animal models of Duchenne muscular dystrophy

The Journal of Clinical Investigation

Skeletal

March 2023

Targeting Fast Muscle Myosin:  A Novel Approach to Protecting Muscle in the Dystrophinopathies

2023 MDA Annual Clinical and Scientific Conference Industry Forum

Skeletal

March 2023

Fast Skeletal Myosin Modulator EDG-5506 Confers Additional Protection to mdx Mice Receiving Glucocorticoid Treatment

2023 MDA Annual Clinical and Scientific Conference

Skeletal

March 2023

Plasma Metabolic Profiling Suggests Enrichment of Glycolytic Pathways Over Fatty Acid Oxidation in Becker Muscular Dystrophy

2023 MDA Annual Clinical and Scientific Conference

Cardiovascular

March 2023

EDG-7500 (EDG-002), A First-in-Class Targeted Sarcomere Regulator that Preserves Intrinsic Myosin-Motor Function, Normalizes Systolic Function and Eliminates LVOT Obstruction in Cats with Hypertrophic Cardiomyopathy

American College of Cardiology (ACC) Annual Scientific Session & Expo 2023

Skeletal

October 2022

Targeting Fast Muscle Myosin: A Novel Approach to Protecting Muscle in the Dystrophinopathies

2022 Annual Congress of the World Muscle Society

Skeletal

October 2022

Clinical Development of EDG-5506 in Duchenne and Becker Muscular Dystrophy

2022 Annual Congress of the World Muscle Society

Skeletal

October 2022

Patient Reported Aspects of Becker Muscular Dystrophy from The Duchenne Registry a Comprehensive Registry for Duchenne and Becker Muscular Dystrophy (BMD)

2022 Annual Congress of the World Muscle Society

Skeletal

June 2022

Insights into the Becker Muscular Dystrophy Experience from the Duchenne Registry, a Comprehensive Registry for Duchenne and Becker Muscular Dystrophy

2022 PPMD Annual Conference

Skeletal

June 2022

Understanding the Becker Muscular Dystrophy (BMD) Experience from the Patient Perspective: It’s More Than Mild Duchenne

2022 PPMD Annual Conference

Skeletal

June 2022

Use of an Exercise Challenge System to Define a Universal Proteomic Signature of Muscle Injury in a Diverse Set of Adult Individuals with Inherited Myopathy

New Directions Biology and Disease of Skeletal Muscle Conference 2022

Skeletal

May 2022

Manipulating the Dark Side of Muscle Adaptation for Therapeutic Gain

13th Annual GoldLab Symposium

Skeletal

March 2022

EDG 5506 Targets Fast Skeletal Myosin to Protect Dystrophic Muscle and Reduce Muscle Damage Biomarkers in a Phase 1 Trial in Becker Muscular Dystrophy

2022 MDA Clinical and Scientific Conference

Skeletal

March 2022

EDG-5506 Targets Fast Skeletal Myosin to Protect Dystrophic Muscle and Reduce Muscle Damage Biomarkers in a Phase 1 Trial in Becker Muscular Dystrophy

2022 MDA Clinical and Scientific Conference

Skeletal

May 2021

Elevation of fast but not slow troponin I in the circulation of patients with Becker and Duchenne muscular dystrophy

Muscle & Nerve, March 8, 2021