Edgewise Therapeutics is a new company harnessing proven expertise and understanding of skeletal muscle physiology to develop novel, transformative therapies for serious muscle diseases. Based in Boulder, Colorado, we have built a state-of-the-art muscle research facility to capitalize on new insights into the nature and consequences of muscle adaptation and injury with disease.
Our Approach
Edgewise builds on our extensive experience in drug development and skeletal muscle research. We have built a custom discovery workshop for the discovery and optimization of novel therapeutics for a broad set of indications where skeletal muscle function is compromised. This includes enzymology and high throughput biochemistry, unique capabilities in skeletal and cardiac muscle physiology and in vivo pharmacology, including a broad array of techniques for assessing physical function. Our facilities take maximal advantage of our location within the BioFrontiers Institute, a pioneering interdisciplinary hub within the University of Colorado designed to house both Academic and Industrial research.
Management Team
Kevin Koch, Ph.D.
President and Chief Executive Officer
Kevin Koch, Ph.D., has served as our President, Chief Executive Officer and a member of our board of directors since 2017. Since 2016, he has also served as a Venture Partner with OrbiMed. Dr. Koch has been active in the life science industry for 20+ years with a focus on drug discovery, translational medicine and clinical development. Most recently, Dr. Koch was the Senior Vice President of Drug Discovery: Chemical and Molecular Therapeutics at Biogen where he managed global drug discovery and biomarker development as well as the immunology and hematology teams. From 1998 to 2013, Dr. Koch served as the President, Chief Scientific Officer, Board member and Co-Founder of Array BioPharma Inc. While there, he built a fully integrated R&D team that oversaw the invention of over 20 clinical development candidates in the multiple therapeutic areas. Prior to Array, Dr. Koch held senior positions at Amgen Inc. and Pfizer Central Research. Dr. Koch received a B.S. in Chemistry and Biochemistry from State University of New York, Stony Brook, and his Ph.D. in Organic Chemistry from University of Rochester.
Alan Russell, Ph.D.
Co-Founder and Chief Scientific Officer
Alan Russell, Ph.D., serves as our Co-Founder, Chief Scientific Officer and a member of our board of directors. Previously, Dr. Russell served at GlaxoSmithKline as VP and Head of the Muscle Metabolism Discovery Performance Unit, leading a broad discovery and development effort focused on patients for whom muscle function is compromised. Prior to this, he worked at Cytokinetics Inc, and is the co-inventor of Tirasemtiv and Reldesemtiv, direct muscle sensitizers in clinical trials for Amyotrophic Lateral Sclerosis (ALS). Dr. Russell received a BPharm and Ph.D. from the University of Bath in the UK and Postdoctoral training at Stanford University School of Medicine.
Abby Bronson, M.B.A.
Vice President, Patient Advocacy and External Innovation
Abby Bronson, MBA, joined Edgewise Therapeutics in April 2020 as our Vice President of Patient Advocacy and External Innovation. Abby has recent experience as the SVP of Research Strategy at Parent Project Muscular Dystrophy where she managed the research portfolio and developed novel trial strategies to accelerate the clinical trial process in Duchenne. Prior to PPMD she was the Director of Operations at the Division of Clinical Innovation at NCATS, NIH. She has also had senior positions at MedImmune and Children’s National Medical Center. She holds an MBA from the Wharton School of Business at the University of Pennsylvania and a BA from the University of Vermont.
R. Michael Carruthers
Chief Financial Officer
Michael Carruthers joined Edgewise Therapeutics in September 2020 as our Chief Financial Officer. Mr. Carruthers has over 20 years of experience serving as Chief Financial Officer for publicly-traded biopharmaceutical companies, with extensive experience across corporate finance and strategic planning including IPO’s, secondary offerings and M&A transactions. Most recently, Mr. Carruthers served as fractional Chief Financial Officer for several private and public companies. Previously Mr. Carruthers served as Interim President of Nivalis Therapeutics, a publicly traded company acquired by Alpine Immune Sciences, in 2017 and Chief Financial Officer and Secretary since 2015. From 1998 to 2015, he served as Chief Financial Officer for Array BioPharma Inc., a publicly traded company acquired by Pfizer Inc. Prior to this, he served as Chief Financial Officer of Sievers Instrument, Treasurer and Controller for the Waukesha division of Dover Corporation and Accountant with Coopers & Lybrand. Mr. Carruthers received a B.S. in accounting from the University of Colorado and a M.B.A. from the University of Chicago.
Behrad Derakhshan, Ph.D.
Chief Business Officer
Dr. Behrad Derakhshan joined Edgewise in September 2020 as Chief Business Officer and is responsible for our corporate strategy and business development. Behrad brings more than 10 years of experience in the rare/ultra-rare disease space. Most recently, Behrad served as Chief Business Officer at VectivBio, a clinical-stage biotechnology company focused on developing novel therapeutics across a variety of rare conditions where he was responsible for the company’s capital formation and business development strategy. Behrad previously served as the Head of Business Development at Therachon, a biotechnology company focused on the discovery and development of therapeutics for rare pediatric conditions, until its acquisition by Pfizer Inc. in 2019. Prior to Therachon, he was a Director at Alexion Pharmaceuticals responsible for Business Development and Strategic Evaluation after initially leading the New Products Global Commercial Insights and Analytics team. Earlier in his career, Behrad worked in management consulting, first as a Senior Consultant at Easton Associates and then as an Associate Director at Navigant Consulting. During that time, he advised a number of global pharmaceutical and biotechnology companies across a range of strategic projects. Behrad conducted his postdoctoral training at the Yale School of Medicine and received his Ph.D. in Biochemistry from a joint program between Weill Cornell Medicine, New York and the University of Surrey, UK. He received a First-Class Honors BSc. with distinction in Biochemistry from the University of Surrey.
Kirsten Gruis, M.D., M.S.
Chief Medical Officer
Kirsten Gruis, M.D., M.S. joined Edgewise Therapeutics March 2020 as our Chief Medical Officer. Dr. Gruis is a board-certified Neuromuscular neurologist with recent experience as the Global head of the Neuromuscular franchise leading the development of SMA (spinal muscular atrophy) and DMD (Duchenne muscular dystrophy) therapeutics at Roche. Prior to Roche she was the CMO at Agilis, a gene therapy start-up acquired by PTC Therapeutics as well as having senior positions In DMD programs at both Wave and Pfizer. Dr. Gruis received her M.D. from the University of Iowa and M.S. degree in clinical research design and statistical analysis from the University of Michigan.
Kevin Hunt, Ph.D.
Drug Discovery Consultant
Kevin W. Hunt, Ph.D. is the Executive Director of Drug Discovery for Edgewise Therapeutics. Prior to Edgewise, Dr. Hunt led target validation and preclinical development activities as a faculty member in the Center for Alzheimer’s and Neurodegenerative Diseases at The University of Texas Southwestern Medical Center. Before UTSW, Dr. Hunt was Site Head of the Calico Life Science outpost in Dallas where he focused on novel treatments for Parkinson’s disease and evaluated potential new targets. Dr. Hunt began his career at Array BioPharma in Boulder leading teams that discovered multiple clinical and pre-clinical candidates for allergic diseases, oncology, and neurogenerative disorders. Dr. Hunt was a Presidential Honors Scholar at Tarleton State University where he received his B.S. in Chemistry. Dr. Hunt earned a Ph.D. in Organic Chemistry from Indiana University and was a George E. Hewitt Foundation for Medical Research Postdoctoral Fellow at The Scripps Research Center.
Nicole Kilburn, M.S., M.B.A.
Executive Director, Regulatory and Program Management
Nicole (Rempel) Kilburn is the Executive Director of Regulatory and Program Management at Edgewise Therapeutics. Ms. Kilburn has 18 years of experience in the pharmaceutical and biotechnology industry focused on project management, drug development strategy and execution, and regulatory affairs. Most recently, Nicole served as Sr. Director of Regulatory & Strategic Development with Clinipace and supported companies from Asia Pacific, EU, Latin America, and North America with drug and biologic life cycle management, from pre-IND through marketing application and approval. She has been responsible for the assembly and submission of applications to competent authorities, including US and EU marketing applications for a recombinant osteoporosis combination product, a dental analgesic combination product and an ophthalmology gene therapy product. Ms. Kilburn received a M.S. in Microbiology & Immunology from Albert Einstein College of Medicine and a M.B.A. from the University of Utah.
John Moore
General Counsel
John Moore joined Edgewise Therapeutics in September 2020 as our General Counsel. He has many years experience as General Counsel for small molecule biopharmaceutical companies working in a range of therapeutic areas. Mr. Moore was most recently General Counsel and Secretary at Peloton Therapeutics, where he led the legal aspects of the company’s initial public offering efforts and advised on its acquisition by Merck on the eve of its planned IPO. Prior to Peloton, Mr. Moore served for 15 years as General Counsel and Secretary at Array BioPharma, Inc., and for 5 years on the board of directors of Nivalis Therapeutics. Prior to Array, he was an attorney in private practice with Wilson Sonsini. Mr. Moore holds a B.S. in chemistry from the University of North Carolina, an M.S. in biochemistry from the University of Illinois and a J.D. from the University of North Carolina.
Board of Directors
Peter Thompson, M.D.
Chairman and Co-Founder
Peter Thompson, M.D., serves as a member of our board of directors and is a Partner on the private equity team at OrbiMed, with over 25 years of industry experience. He held executive positions at Becton-Dickinson and Chiron, co-founded and was CEO of Trubion Pharmaceuticals, co-founded Corvus Pharmaceuticals, Cleave Biosciences, Silverback Therapeutics and serves as a Director on several company boards. Dr. Thompson is an Ernst & Young Entrepreneur of the Year awardee, an Affiliate Professor of Neurosurgery at the University of Washington, an inventor on numerous patents and a board-certified internist and oncologist. He was on staff at the National Cancer Institute following his internal medicine training at Yale University.
Kevin Koch, Ph.D.
Director
Kevin Koch, Ph.D., has served as our President, Chief Executive Officer and a member of our board of directors since 2017. Since 2016, he has also served as a Venture Partner with OrbiMed. Dr. Koch has been active in the life science industry for 20+ years with a focus on drug discovery, translational medicine and clinical development. Most recently, Dr. Koch was the Senior Vice President of Drug Discovery: Chemical and Molecular Therapeutics at Biogen where he managed global drug discovery and biomarker development as well as the immunology and hematology teams. From 1998 to 2013, Dr. Koch served as the President, Chief Scientific Officer, Board member and Co-Founder of Array BioPharma Inc. While there, he built a fully integrated R&D team that oversaw the invention of over 20 clinical development candidates in the multiple therapeutic areas. Prior to Array, Dr. Koch held senior positions at Amgen Inc. and Pfizer Central Research. Dr. Koch received a B.S. in Chemistry and Biochemistry from State University of New York, Stony Brook, and his Ph.D. in Organic Chemistry from University of Rochester.
Alan Russell, Ph.D.
Director and Co-Founder
Alan Russell, Ph.D., serves as our Co-Founder, Chief Scientific Officer and a member of our board of directors. Previously, Dr. Russell served at GlaxoSmithKline as VP and Head of the Muscle Metabolism Discovery Performance Unit, leading a broad discovery and development effort focused on patients for whom muscle function is compromised. Prior to this, he worked at Cytokinetics Inc, and is the co-inventor of Tirasemtiv and Reldesemtiv, direct muscle sensitizers in clinical trials for Amyotrophic Lateral Sclerosis (ALS). Dr. Russell received a BPharm and Ph.D. from the University of Bath in the UK and Postdoctoral training at Stanford University School of Medicine.
Jon Root, M.D.
Director
Jon Root, M.D., serves as a member of our board of directors and is a General Partner at U.S. Venture Partners, having joined the firm in 1995 as a Ewing Marion Kauffman Fellow in venture capital. Before USVP, Dr. Root was Assistant Professor of Neurology and Director of the Neurology-Neurosurgery Special Care Unit at The New York Hospital-Cornell Medical Center in New York City. He is board certified in neurology.
In addition to Edgewise, Dr. Root is currently on the boards of USVP portfolio companies Cleave Biosciences, eFFECTOR Therapeutics, HealthJoy, Inari Medical, Nuvaira, Okami Medical, Omada Health, Ribon Therapeutics, Route 92 Medical and Swoop. Dr. Root is a former board member for the National Venture Capital Association (NVCA).
Dr. Root holds an A.B. in Economics from Dartmouth College, an M.D. from the University of Florida College of Medicine, and an M.B.A. from Columbia University.
Kenneth Harrison, Ph.D.
Director
Kenneth Harrison, Ph.D., serves as a member of our board of directors and joined Novo Ventures (US) Inc. in San Francisco, California in 2015. Dr. Harrison currently serves on the boards of Glycomine and Aristea Therapeutics, and while at Novo has been involved with investments in Bolt Biotherapeutics, Mirum Pharma (NASDAQ: MIRM) and ViewPoint Therapeutics.
Prior to joining Novo Ventures, Dr. Harrison worked in strategic planning at Genentech, as a life sciences management consultant at L.E.K. Consulting and as a seed-stage investor at QB3/Mission Bay Capital, where he also helped create programs to launch and build life sciences companies in the Bay Area.
Dr. Harrison studied cellular lipid storage and metabolism as an A.P. Giannini Foundation Fellow at the J. David Gladstone Institutes and earned a Ph.D. in Pharmacology from Yale University.
Badreddin Edris, Ph.D.
Observer and Co-Founder
Badreddin Edris, Ph.D., is a co-founder of Edgewise Therapeutics and continues to serve as a board observer and strategic advisor after having been the company’s founding Chief Operating Officer. Dr. Edris is currently the Chief Business Officer of SpringWorks Therapeutics (NASDAQ: SWTX), a clinical-stage biopharmaceutical company focused on rare diseases and cancer. At SpringWorks, Dr. Edris leads the company’s strategic planning, business development, capital formation, investor relations, and competitive intelligence efforts. Prior to joining SpringWorks, Dr. Edris was an investment and operating professional on the private equity team at OrbiMed, where he was involved in deal sourcing, evaluation and execution, as well as post-investment strategic and operational support for biotechnology companies across a range of therapeutic areas and stages of development. In addition to Edgewise, Dr. Edris also co-founded Silverback Therapeutics while at OrbiMed and served as the company’s chief business officer. Before OrbiMed, Dr. Edris was a management consultant at Bain & Company, where he collaborated with global pharmaceutical and biotechnology companies on a range of strategic and operational projects. Dr. Edris received his Ph.D. in genetics from Stanford University, where he was an NSF research fellow.
Scientific Advisory Board
Leslie Leinwand
Chief Scientific Officer, BioFrontiers Institute • Professor CU Boulder
Leslie Leinwand, Ph.D. is a Molecular, Cellular, and Developmental Biology (MCDB) Distinguished Professor and the Chief Scientific Officer of the BioFrontiers Institute at the University of Colorado Boulder. She was recruited to be Chair of MCDB in 1995. She received her Bachelor’s degree from Cornell University, her Ph.D. from Yale University and did post-doctoral training at Rockefeller University. She joined the faculty at Albert Einstein College of Medicine in New York in 1981 and remained there until moving to Colorado in 1995. She co-founded Myogen, Inc. which was sold to Gilead Pharmaceuticals. She was also a co-founder of Hiberna, Inc, and more recently of MyoKardia, Inc, a publicly traded company founded to develop therapeutics for inherited cardiomyopathies. She is a Fellow of the AAAS, former MERIT Awardee of the NIH, Established Investigator of the American Heart Association and was recently elected to the American Academy of Arts and Sciences and the National Academy of Inventors. The interests of Dr. Leinwand’s laboratory are the genetics and molecular physiology of inherited diseases of the heart and how gender and diet modify the heart. The study of these diseases has required multidisciplinary approaches, involving molecular biology, mouse genetics, mouse cardiac physiology, and the analysis of human tissues. Her teaching was recognized by funding from the Howard Hughes Medical Institute’s Professor Program.
Lee Sweeney
Professor at University of Florida, and Director of the Myology Institute
Much of Dr. Sweeney’s research program is translational in focus and has produced highly cited research on inherited forms of cardiovascular disease and on the skeletal and cardiac aspects of muscular dystrophy. Dr. Sweeney was elected as a Fellow of the American Heart Association in 2001. He has been the director of a Paul Wellstone Muscular Dystrophy Cooperative Center since 2005, which is now competing for renewal as a University of Florida (UF) Wellstone Muscular Dystrophy Cooperative Center. Dr. Sweeney is actively developing therapeutics for rare diseases that include both small molecule and gene therapy approaches. He serves as a consultant to a number of industry therapeutic development efforts for Duchenne muscular dystrophy and spinal muscular atrophy.
Dr. Sweeney is well-known in the popular press for his gene-therapy approaches to permanently block the loss of age-related muscle size and strength in mice. The technique suggests that therapies for humans could reverse the feebleness associated with old age or slow the muscle-wasting effects of muscular dystrophies. Based on the enhancement this creates in healthy young animals, Dr. Sweeney has been widely sought as an expert commentator on the potential for gene “doping” in sports, as well as on the bioethical issues surrounding genetic enhancement. In 2004, this work led to Dr. Sweeney being among those chosen by Esquire Magazine as the “Best and Brightest” in America.
Dr. Sweeney is also heavily involved in small molecule therapy development for muscle disease. In 2007, he and his collaborators at PTC Therapeutics (a small NJ biotech company) published the development of a compound (PTC 124 or ataluren) that allows read-through of nonsense mutations (premature stop codons) in a variety of genetic disease models. The drug is in clinical trials for Duchenne muscular dystrophy and Cystic Fibrosis. For this work, Dr. Sweeney was awarded a Hamdan Award for Medical Research Excellence from Sheikh Hamdan of Dubai in 2008. On May 23, 2014, ataluren was granted conditional European approval for the treatment of Duchenne muscular dystrophy (DMD), making it the first approved drug for this disease.
Barry Byrne
Director of the Powell Gene Therapy Center at the University of Florida, and Associate Chair of Pediatrics
Dr. Barry J. Byrne is a clinician scientist interested in a variety of rare diseases, with specific attention to developing therapies for inherited muscle disease. As a pediatric cardiologist, his focus is on conditions that lead to skeletal muscle weakness, cardiac dysfunction and respiratory dysfunction. His research team has made significant contributions to the understanding and treatment of Pompe disease, a type of muscular dystrophy resulting from abnormal glycogen accumulation in the muscle. His current research has focused on developing new therapies using the missing cellular protein or the corrective gene to restore muscle function in Pompe and other inherited myopathies.
Dr. Barry Byrne is the Associate Chair of Pediatrics and Director of the Powell Gene Therapy Center at the University of Florida. After obtaining a B.S. degree in Chemistry from Denison University, he pursued his medical education, as well as a Ph.D. in Microbiology and Immunology, at the University of Illinois. He completed his pediatric residency, cardiology fellowship training and post-doctoral training in Biological Chemistry at Johns Hopkins University. Joining the University of Florida in 1997, he has served in a variety of clinical, research and educational roles, and is now the Earl and Christy Powell University Chair in Genetics.
Craig McDonald
Professor of Pediatrics and Physical Medicine and Rehabilitation, and Chair of the Department of Physical Medicine & Rehabilitation at UC Davis
Craig McDonald, M.D. is a an internationally recognized expert in the clinical management, rehabilitation, and precision therapeutics for children and adults with muscle diseases. He has been a pioneer in the development of novel outcome measures for clinical trials in disabled populations. He is widely known for his expertise in the treatment and evaluation of children and young adults with Duchenne muscular dystrophy (DMD). He leads the international Cooperative International Neuromuscular Research Group (CINRG) Duchenne Natural History Study, a collaborative effort which has made seminal contributions to the elucidation of the natural history of DMD and validation of the clinical endpoints now used in clinical trials of DMD throughout the world.