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Edgewise

Edgewise Therapeutics

A Movement in Muscle

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    Our vision is to improve the lives of patients and families suffering from serious muscle diseases by building the world’s leading muscle-focused company.

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    • Sevasemten
    • EDG-7500
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    All of us at Edgewise are committed to developing new medicines for people facing serious muscle diseases with unmet medical needs.

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    • Muscular Dystrophy
    • Cardiovascular Diseases

    Learn more about how our science is driving a new understanding of muscle and its potential to transform human health.

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    We honor the experience of individuals and families living with and facing the challenges of serious muscle disease.

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HomeSciencePipeline

Pipeline

Advancing novel precision therapeutics for serious muscle disease

Muscular Dystrophy

Program
Indications
Preclinical Phase 1 Phase 2 Pivotal /
Phase 3
Regulatory Submission

Sevasemten*

Myosin ATPase

Becker

Pivotal / Phase 3

Sevasemten is an orally-administered first-in-class fast myosin inhibitor designed to preserve and protect dystrophic muscle against contraction-induced damage in dystrophinopathies including Becker and Duchenne.

Learn more about sevasemten clinical trials

Sevasemten*

Myosin ATPase

Duchenne

Phase 2

Sevasemten is an orally-administered first-in-class fast myosin inhibitor designed to preserve and protect dystrophic muscle against contraction-induced damage in dystrophinopathies including Becker and Duchenne.

Learn more about sevasemten clinical trials

Sevasemten*

Myosin ATPase

Becker, LGMD2i, McArdle

Phase 2

Sevasemten is an orally-administered first-in-class fast myosin inhibitor designed to preserve and protect dystrophic muscle against contraction-induced damage in dystrophinopathies including Becker and Duchenne.

Learn more about sevasemten clinical trials

Cardiovascular

Program
Indications
Preclinical Phase 1 Phase 2 Pivotal /
Phase 3
Regulatory Submission

EDG-7500*

Undisclosed Cardiac Sarcomeric Target

Hypertrophic Cardiomyopathy

Phase 2

EDG-7500 is a novel oral, selective, cardiac sarcomere modulator for the treatment of HCM.

Learn more about EDG-7500 clinical trials

EDG-15400*

Undisclosed Cardiac SarcomericTarget

HFpEF

Phase 1

EDG-15400 is a novel oral, selective, cardiac sarcomere modulator, for the treatment of HFpEF and other diseases of diastolic dysfunction

Learn more about EDG-15400 clinical trials

EDG-003

Undisclosed Target

Cardiometabolic

Preclinical

*Sevasemten, EDG-7500, EDG-15400, and other undisclosed cardiac sarcomeric agents are investigational therapies.
They are not approved in any territory, and their safety and effectiveness have not been established.

Is a clinical trial right for you?

We are currently conducting clinical trials in muscular dystrophies and severe cardiovascular disease.

Learn more about Edgewise clinical trials

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We are advancing novel precision therapeutics for serious muscle disease.

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    • EDG-15400
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    • Cardiovascular Diseases
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    • Support for Duchenne
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